HIPK1 Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily. Ubiquitously expressed with highest levels in skeletal muscle and heart. Overexpressed in breast cancer cell lines. Isoform 2 is highly expressed in testis. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CMGC group; DYRK family; EC 2.7.11.1; HIPK subfamily; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 3|3 F2.2
Cellular Component:  centrosome; cytoplasm; cytosol; nuclear speck; nucleoplasm; nucleus; PML body
Molecular Function:  ATP binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transcription corepressor activity; transferase activity
Biological Process:  adherens junction assembly; anterior/posterior pattern specification; embryonic camera-type eye morphogenesis; embryonic retina morphogenesis in camera-type eye; endothelial cell apoptotic process; extrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; iris morphogenesis; lens induction in camera-type eye; negative regulation of transcription by RNA polymerase II; neuron differentiation; phosphorylation; positive regulation of cell proliferation; positive regulation of DNA binding; protein phosphorylation; regulation of tumor necrosis factor-mediated signaling pathway; retina layer formation; smoothened signaling pathway
Reference #:  O88904 (UniProtKB)
Alt. Names/Synonyms: 1110062K04Rik; Hipk1; homeodomain interacting protein kinase 1; Homeodomain-interacting protein kinase 1; Kiaa0630; Mya; Myak; Nbak2; Nuclear body-associated kinase 2; Protein kinase Myak
Gene Symbols: Hipk1
Molecular weight: 130,723 Da
Basal Isoelectric point: 8.49  Predict pI for various phosphorylation states
Select Structure to View Below

HIPK1

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene