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C8A
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself. Belongs to the complement C6/C7/C8/C9 family. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, multi-pass |
| Chromosomal Location of human Ortholog: 1p32.2 |
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Cellular Component:
extracellular region; extracellular space; membrane; membrane attack complex
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Molecular Function:
complement binding; protein binding; protein-containing complex binding
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Biological Process:
complement activation; complement activation, alternative pathway; complement activation, classical pathway; cytolysis; immune response; positive regulation of immune response
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Disease: Complement Component 8 Deficiency, Type I
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Reference #:
P07357
(UniProtKB)
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Alt. Names/Synonyms: C8A; CO8A; complement C8 alpha chain; complement component 8 alpha subunit; Complement component 8 subunit alpha; complement component 8, alpha polypeptide; Complement component C8 alpha chain
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Gene Symbols: C8A
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Molecular weight:
65,163 Da
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Basal Isoelectric point:
6.07
Predict pI for various phosphorylation states
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