C8A Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself. Belongs to the complement C6/C7/C8/C9 family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass
Chromosomal Location of human Ortholog: 1p32.2
Cellular Component:  extracellular region; extracellular space; membrane; membrane attack complex
Molecular Function:  complement binding; protein binding; protein-containing complex binding
Biological Process:  complement activation; complement activation, alternative pathway; complement activation, classical pathway; cytolysis; immune response; positive regulation of immune response
Disease: Complement Component 8 Deficiency, Type I
Reference #:  P07357 (UniProtKB)
Alt. Names/Synonyms: C8A; CO8A; complement C8 alpha chain; complement component 8 alpha subunit; Complement component 8 subunit alpha; complement component 8, alpha polypeptide; Complement component C8 alpha chain
Gene Symbols: C8A
Molecular weight: 65,163 Da
Basal Isoelectric point: 6.07  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene