RTKN Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin structures. Highly expressed in prostate, moderately in kidney, heart, brain, spleen, testis, placenta, small intestine, pancreas, skeletal muscle and peripheral blood leukocytes, and weakly in ovary, colon and thymus. Weakly expressed in all normal cell lines tested. Overexpressed in various cancer cell lines. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: G protein regulator, misc.
Chromosomal Location of Human Ortholog: 6 C3|6 35.94 cM
Cellular Component:  actomyosin contractile ring
Molecular Function:  GTP binding; GTP-Rho binding; GTPase inhibitor activity; nucleotide binding; protein binding; Rho GTPase binding
Biological Process:  actomyosin contractile ring assembly; apoptotic process; cortical cytoskeleton organization; mitotic cytokinesis; protein localization to mitotic actomyosin contractile ring; regulation of apoptotic process; Rho protein signal transduction; septin cytoskeleton organization; septin ring organization; signal transduction
Reference #:  Q8C6B2 (UniProtKB)
Alt. Names/Synonyms: Rhotekin; Rtkn
Gene Symbols: Rtkn
Molecular weight: 63,013 Da
Basal Isoelectric point: 6.23  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene