MCL1 Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis. Belongs to the Bcl-2 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Channel, misc.; Inhibitor; Membrane protein, integral; Mitochondrial
Chromosomal Location of mouse Ortholog: 3 F2.1|3 40.74 cM
Cellular Component:  Bcl-2 family protein complex; cytoplasm; cytosol; integral component of membrane; membrane; mitochondrial matrix; mitochondrial outer membrane; mitochondrion; nucleus
Molecular Function:  BH domain binding; BH3 domain binding; protein binding; protein dimerization activity; protein heterodimerization activity; protein homodimerization activity
Biological Process:  apoptotic mitochondrial changes; apoptotic process; cell differentiation; extrinsic apoptotic signaling pathway in absence of ligand; intrinsic apoptotic signaling pathway in response to DNA damage; multicellular organism development; negative regulation of anoikis; negative regulation of apoptotic process; negative regulation of autophagy; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of intrinsic apoptotic signaling pathway; positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; regulation of apoptotic process; regulation of response to DNA damage stimulus; response to cytokine
Reference #:  P97287 (UniProtKB)
Alt. Names/Synonyms: AW556805; Bcl-2-related protein EAT/mcl1; Induced myeloid leukemia cell differentiation protein Mcl-1 homolog; Mcl-; Mcl-1; Mcl1; myeloid cell leukemia sequence 1
Gene Symbols: Mcl1
Molecular weight: 35,217 Da
Basal Isoelectric point: 5.88  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  IL6 Signaling  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene