MCL1 Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis. Belongs to the Bcl-2 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Channel, misc.; Inhibitor; Membrane protein, integral; Mitochondrial
Chromosomal Location of human Ortholog: 1q21.2
Cellular Component:  Bcl-2 family protein complex; cytoplasm; cytosol; membrane; mitochondrial outer membrane; mitochondrion; nucleoplasm; nucleus
Molecular Function:  BH3 domain binding; channel activity; protein binding; protein heterodimerization activity; protein homodimerization activity; protein transmembrane transporter activity
Biological Process:  cell fate determination; cellular homeostasis; DNA damage response; extrinsic apoptotic signaling pathway in absence of ligand; intrinsic apoptotic signaling pathway in response to DNA damage; mitochondrial fusion; negative regulation of anoikis; negative regulation of apoptotic process; negative regulation of autophagy; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of apoptotic process; positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; protein transmembrane transport; release of cytochrome c from mitochondria; response to cytokine
Reference #:  Q07820 (UniProtKB)
Alt. Names/Synonyms: Bcl-2-like protein 3; Bcl-2-related protein EAT/mcl1; BCL2 family apoptosis regulator; Bcl2-L-3; BCL2L3; EAT; Induced myeloid leukemia cell differentiation protein Mcl-1; Mcl-1; MCL1; MCL1 apoptosis regulator, BCL2 family member; MCL1, BCL2 family apoptosis regulator; MCL1-ES; mcl1/EAT; MCL1L; MCL1S; MGC104264; MGC1839; myeloid cell leukemia 1; myeloid cell leukemia ES; myeloid cell leukemia sequence 1 (BCL2-related); myeloid cell leukemia sequence 1, isoform 1; TM
Gene Symbols: MCL1
Molecular weight: 37,337 Da
Basal Isoelectric point: 5.51  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  IL6 Signaling  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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MCL1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein