MEK5 Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. Expressed in many adult tissues. Abundant in heart and skeletal muscle. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; MEK5 subfamily; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor); STE group; STE7 family
Chromosomal Location of mouse Ortholog: 9|9 B-C
Cellular Component:  cytoplasm; spindle
Molecular Function:  ATP binding; kinase activity; MAP kinase kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; protein tyrosine kinase activity; transferase activity
Biological Process:  cellular response to growth factor stimulus; ERK5 cascade; heart development; insulin-like growth factor receptor signaling pathway; MAPK cascade; negative regulation of cell migration involved in sprouting angiogenesis; negative regulation of chemokine (C-X-C motif) ligand 2 production; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of heterotypic cell-cell adhesion; negative regulation of interleukin-8 production; negative regulation of NF-kappaB transcription factor activity; negative regulation of response to cytokine stimulus; negative regulation of transcription by RNA polymerase II; phosphorylation; positive regulation of cell growth; positive regulation of epithelial cell proliferation; positive regulation of MAP kinase activity; positive regulation of protein metabolic process; positive regulation of transcription by RNA polymerase II; protein phosphorylation
Reference #:  Q9WVS7 (UniProtKB)
Alt. Names/Synonyms: AI324775; AI428457; Dual specificity mitogen-activated protein kinase kinase 5; MAP kinase kinase 5; Map2k5; MAPK/ERK kinase 5; MAPK/ERK kinese 5; MAPKK 5; Mapkk5; MEK 5; Mek5; mitogen activated protein kinase kinase 5; mitogen-activated protein kinase kinase 5; Mkk5; MP2K5; Prkmk5
Gene Symbols: Map2k5
Molecular weight: 50,105 Da
Basal Isoelectric point: 5.92  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  IL6 Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene