WDR81 Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport. It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome. May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates. In this process, may regulate the interaction of SQSTM1 with ubiquitinated proteins and also recruit MAP1LC3C. May also be involved in maintenance of normal mitochondrial structure and organization. Belongs to the WD repeat WDR81 family. Widely expressed. In the brain, highest levels in cerebellum and corpus callosum. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 17p13.3
Cellular Component:  autophagosome membrane; cytosol; early endosome membrane; extrinsic component of endosome membrane; late endosome membrane; lysosomal membrane; mitochondrion
Molecular Function:  K63-linked polyubiquitin modification-dependent protein binding; phosphatidylinositol 3-kinase regulator activity; protein binding
Biological Process:  aggrephagy; early endosome to late endosome transport; mitochondrion organization; negative regulation of phosphatase activity; protein stabilization; regulation of phosphatidylinositol 3-kinase activity; ubiquitin-dependent protein catabolic process
Disease: Cerebellar Ataxia, Mental Retardation, And Dysequilibrium Syndrome 2; Hydrocephalus, Congenital, 3, With Brain Anomalies
Reference #:  Q562E7 (UniProtKB)
Alt. Names/Synonyms: CAMRQ2; FLJ23776; FLJ33817; HYC3; PPP1R166; protein phosphatase 1, regulatory subunit 166; SORF-2; WD repeat domain 81; WD repeat-containing protein 81; WDR81
Gene Symbols: WDR81
Molecular weight: 211,697 Da
Basal Isoelectric point: 5.37  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene