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ILKAP
Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation. Belongs to the PP2C family. Widely expressed. Highest levels expressed in striated muscle. Much lower levels evident in various smooth muscle tissues. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.1.3.16; Motility/polarity/chemotaxis; Protein phosphatase, Ser/Thr (non-receptor) |
| Chromosomal Location of human Ortholog: 2q37.3 |
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Cellular Component:
cytoplasm
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Molecular Function:
metal ion binding; myosin phosphatase activity; protein binding
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Biological Process:
protein dephosphorylation
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Reference #:
Q9H0C8
(UniProtKB)
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Alt. Names/Synonyms: DKFZp434J2031; FLJ10181; ILK associated serine/threonine phosphatase; ILKAP; ILKAP2; ILKAP3; integrin-linked kinase associated phosphatase; integrin-linked kinase-associated protein phosphatase 2C; Integrin-linked kinase-associated serine/threonine phosphatase 2C; MGC4846; PP2C-DELTA; PP2CD; PPM1O; protein phosphatase 2c, delta isozyme; protein phosphatase, Mg2+/Mn2+ dependent 1O
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Gene Symbols: ILKAP
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Molecular weight:
42,907 Da
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Basal Isoelectric point:
6.68
Predict pI for various phosphorylation states
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