ILKAP Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation. Belongs to the PP2C family. Widely expressed. Highest levels expressed in striated muscle. Much lower levels evident in various smooth muscle tissues. Note: This description may include information from UniProtKB.
Protein type: EC; Motility/polarity/chemotaxis; Protein phosphatase, Ser/Thr (non-receptor)
Chromosomal Location of human Ortholog: 2q37.3
Cellular Component:  cytoplasm
Molecular Function:  metal ion binding; myosin phosphatase activity; protein binding
Biological Process:  protein dephosphorylation
Reference #:  Q9H0C8 (UniProtKB)
Alt. Names/Synonyms: DKFZp434J2031; FLJ10181; ILK associated serine/threonine phosphatase; ILKAP; ILKAP2; ILKAP3; integrin-linked kinase associated phosphatase; integrin-linked kinase-associated protein phosphatase 2C; Integrin-linked kinase-associated serine/threonine phosphatase 2C; MGC4846; PP2C-DELTA; PP2CD; PPM1O; protein phosphatase 2c, delta isozyme; protein phosphatase, Mg2+/Mn2+ dependent 1O
Gene Symbols: ILKAP
Molecular weight: 42,907 Da
Basal Isoelectric point: 6.68  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein