EIF5A2 mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. Belongs to the eIF-5A family. Expressed in ovarian and colorectal cancer cell lines (at protein level). Highly expressed in testis. Overexpressed in some cancer cells. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 3q26.2
Cellular Component:  cytosol; endoplasmic reticulum membrane; intracellular membrane-bounded organelle; nuclear pore
Molecular Function:  protein binding; ribosome binding; translation elongation factor activity
Biological Process:  mRNA transport; polyamine homeostasis; positive regulation of cell proliferation; positive regulation of translational elongation; positive regulation of translational termination; protein transport; spermatogenesis; translational frameshifting
Reference #:  Q9GZV4 (UniProtKB)
Alt. Names/Synonyms: eIF-5A-2; eIF-5A2; EIF5A2; eIF5AII; eukaryotic initiation factor 5A; Eukaryotic initiation factor 5A isoform 2; Eukaryotic translation initiation factor 5A-2; eukaryotic translation initiation factor 5A2; IF5A2
Gene Symbols: EIF5A2
Molecular weight: 16,793 Da
Basal Isoelectric point: 5.38  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein