SMAD4 transcription factor that mediates signal transduction by the transforming growth factor superfamily. The common smad (co-smad). Binds directly to consensus DNA-binding elements in the promoters of target genes. Promotes binding of the Smad2/Smad4/Fast-1 complex to DNA and provides an activation function required for Smad1 or Smad2 to stimulate transcription. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 18q21.2
Cellular Component:  activin responsive factor complex; centrosome; cytoplasm; cytosol; nuclear chromatin; nucleoplasm; nucleus; SMAD protein complex; transcription factor complex
Molecular Function:  chromatin binding; collagen binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; I-SMAD binding; identical protein binding; metal ion binding; protein binding; protein heterodimerization activity; protein homodimerization activity; proximal promoter sequence-specific DNA binding; R-SMAD binding; RNA polymerase II proximal promoter sequence-specific DNA binding; RNA polymerase II transcription factor binding; sulfate binding; transcription coregulator activity; transcription regulatory region DNA binding; transforming growth factor beta receptor, common-partner cytoplasmic mediator activity
Biological Process:  atrioventricular canal development; atrioventricular valve formation; axon guidance; BMP signaling pathway; brainstem development; branching involved in ureteric bud morphogenesis; cell proliferation; cellular iron ion homeostasis; cellular response to BMP stimulus; developmental growth; embryonic digit morphogenesis; endocardial cell differentiation; endoderm development; endothelial cell activation; epithelial to mesenchymal transition involved in endocardial cushion formation; female gonad morphogenesis; formation of anatomical boundary; gastrulation with mouth forming second; in utero embryonic development; interleukin-6-mediated signaling pathway; intracellular signal transduction; left ventricular cardiac muscle tissue morphogenesis; mesoderm development; metanephric mesenchyme morphogenesis; negative regulation of cardiac muscle hypertrophy; negative regulation of cardiac myofibril assembly; negative regulation of cell death; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of ERK1 and ERK2 cascade; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; nephrogenic mesenchyme morphogenesis; neural crest cell differentiation; neuron fate commitment; outflow tract septum morphogenesis; ovarian follicle development; positive regulation of BMP signaling pathway; positive regulation of cell proliferation involved in heart valve morphogenesis; positive regulation of epithelial to mesenchymal transition; positive regulation of follicle-stimulating hormone secretion; positive regulation of histone H3-K4 methylation; positive regulation of histone H3-K9 acetylation; positive regulation of luteinizing hormone secretion; positive regulation of pathway-restricted SMAD protein phosphorylation; positive regulation of SMAD protein signal transduction; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus; positive regulation of transcription, DNA-templated; positive regulation of transforming growth factor beta receptor signaling pathway; pri-miRNA transcription by RNA polymerase II; protein deubiquitination; protein homotrimerization; regulation of binding; regulation of hair follicle development; regulation of transforming growth factor beta receptor signaling pathway; regulation of transforming growth factor beta2 production; response to hypoxia; response to transforming growth factor beta; sebaceous gland development; secondary palate development; seminiferous tubule development; single fertilization; SMAD protein complex assembly; SMAD protein signal transduction; somatic stem cell population maintenance; somite rostral/caudal axis specification; spermatogenesis; transforming growth factor beta receptor signaling pathway; uterus development; ventricular septum morphogenesis
Disease: Juvenile Polyposis Syndrome; Juvenile Polyposis/hereditary Hemorrhagic Telangiectasia Syndrome; Myhre Syndrome; Pancreatic Cancer
Reference #:  Q13485 (UniProtKB)
Alt. Names/Synonyms: deleted in pancreatic carcinoma locus 4; Deletion target in pancreatic carcinoma 4; DPC4; hSMAD4; JIP; MAD homolog 4; MAD, mothers against decapentaplegic homolog 4; MADH4; Mothers against decapentaplegic homolog 4; mothers against decapentaplegic, Drosophila, homolog of, 4; Mothers against DPP homolog 4; SMAD 4; SMAD family member 4; SMAD, mothers against DPP homolog 4; SMAD4
Gene Symbols: SMAD4
Molecular weight: 60,439 Da
Basal Isoelectric point: 6.5  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  G1/S Checkpoint  |  SAPK/JNK Signaling Cascades  |  TGF-ß Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  InnateDB