PRPF4
Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: RNA processing; RNA splicing; Spliceosome |
Chromosomal Location of human Ortholog: 9q32 |
Cellular Component:
Cajal body; nuclear speck; nucleoplasm; nucleus; spliceosomal complex; spliceosomal snRNP complex; U2-type precatalytic spliceosome; U4/U6 snRNP; U4/U6 x U5 tri-snRNP complex
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Molecular Function:
protein binding; U4 snRNA binding; U6 snRNA binding
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Biological Process:
mRNA splicing, via spliceosome; RNA processing; RNA splicing; RNA splicing, via transesterification reactions
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Disease: Retinitis Pigmentosa 70
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Reference #:
O43172
(UniProtKB)
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Alt. Names/Synonyms: hPrp4; HPRP4P; pre-mRNA processing factor 4; PRP4; PRP4 homolog; PRP4 pre-mRNA processing factor 4 homolog; PRP4 pre-mRNA processing factor 4 homolog (yeast); PRP4/STK/WD splicing factor; Prp4p; PRPF4; RP70; SNRNP60; U4/U6 small nuclear ribonucleoprotein Prp4; U4/U6 snRNP 60 kDa protein; WD splicing factor Prp4
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Gene Symbols: PRPF4
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Molecular weight:
58,449 Da
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Basal Isoelectric point:
7.05
Predict pI for various phosphorylation states
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