UBE2D2 Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3. Belongs to the ubiquitin-conjugating enzyme family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 18|18 B2
Cellular Component:  protein-containing complex; ubiquitin ligase complex
Molecular Function:  ATP binding; nucleotide binding; protein binding; transferase activity; ubiquitin conjugating enzyme activity; ubiquitin protein ligase binding; ubiquitin-protein transferase activity
Biological Process:  protein autoubiquitination; protein K11-linked ubiquitination; protein K48-linked ubiquitination; protein polyubiquitination; protein ubiquitination; ubiquitin-dependent protein catabolic process
Reference #:  P62838 (UniProtKB)
Alt. Names/Synonyms: 1500034D03Rik; E2(17)KB 2; UB2D2; Ubc2e; Ubc4; Ube2d2; Ubiquitin carrier protein D2; ubiquitin conjugating enzyme 2e; Ubiquitin-conjugating enzyme E2 D2; Ubiquitin-conjugating enzyme E2(17)KB 2; Ubiquitin-conjugating enzyme E2-17 kDa 2; ubiquitin-conjugating enzyme E2D 2; Ubiquitin-protein ligase D2
Gene Symbols: Ube2d2
Molecular weight: 16,735 Da
Basal Isoelectric point: 7.69  Predict pI for various phosphorylation states
CST Pathways:  NF-kB Signaling
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene