ZBTB1 Acts as a transcriptional repressor. Represses cAMP-responsive element (CRE)-mediated transcriptional activation. In addition, has a role in translesion DNA synthesis. Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruitment to replication factories and efficient translesion DNA synthesis. Plays a key role in the transcriptional regulation of T lymphocyte development. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein
Chromosomal Location of Human Ortholog: 14q23.3
Cellular Component:  nuclear body; nuclear membrane; nucleoplasm; nucleus
Molecular Function:  DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; K63-linked polyubiquitin modification-dependent protein binding; metal ion binding; protein binding; protein heterodimerization activity; protein homodimerization activity
Biological Process:  B cell differentiation; cellular response to DNA damage stimulus; cellular response to UV; chromatin remodeling; DNA repair; innate immune response; mRNA transcription by RNA polymerase II; negative regulation of transcription by RNA polymerase II; positive regulation of natural killer cell differentiation; positive regulation of pro-T cell differentiation; positive regulation of T cell differentiation; positive regulation of T cell mediated immunity; protein homooligomerization; T cell differentiation in thymus; thymus development; translesion synthesis
Reference #:  Q9Y2K1 (UniProtKB)
Alt. Names/Synonyms: KIAA0997; ZBTB1; zinc finger and BTB domain containing 1; Zinc finger and BTB domain-containing protein 1; ZNF909
Gene Symbols: ZBTB1
Molecular weight: 82,016 Da
Basal Isoelectric point: 5.97  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein