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GANP
Isoform GANP: As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores. Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations. Isoform MCM3AP: Binds to and acetylates the replication protein MCM3. Plays a role in the initiation of DNA replication and participates in controls that ensure that DNA replication initiates only once per cell cycle. Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations. Belongs to the SAC3 family. Widely expressed (PubMed:11024281). Up-regulated in germinal center B-cells in tonsils (at protein level) (PubMed:11024281). 2 human isoforms generated by alternative promoter usage have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Acetyltransferase; Karyopherin |
| Chromosomal Location of human Ortholog: 21q22.3 |
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Cellular Component:
chromosome; cytoplasm; cytosol; nuclear membrane; nuclear pore nuclear basket; nucleoplasm; nucleus; transcription export complex 2
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Molecular Function:
chromatin binding; histone acetyltransferase activity; histone binding; histone H3 acetyltransferase activity; nucleic acid binding; protein binding
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Biological Process:
mRNA export from nucleus; nucleosome organization; poly(A)+ mRNA export from nucleus; protein transport; somatic hypermutation of immunoglobulin genes
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Disease: Peripheral Neuropathy, Autosomal Recessive, With Or Without Impaired Intellectual Development
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Reference #:
O60318
(UniProtKB)
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Alt. Names/Synonyms: 80 kDa MCM3-associated protein; FLJ44336; FLJ45306; GANP; germinal center-associated nuclear protein; Germinal-center associated nuclear protein; germinal-centre associated nuclear protein; KIAA0572; MAP80; MCM3 acetylating protein; MCM3 acetyltransferase; MCM3 import protein; MCM3 minichromosome maintenance deficient 3 associated protein; MCM3A; MCM3AP; minichromosome maintenance complex component 3 associated protein; minichromosome maintenance deficient 3-associated protein; PNRIID; Protein GANP; SAC3
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Gene Symbols: MCM3AP
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Molecular weight:
218,405 Da
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Basal Isoelectric point:
5.99
Predict pI for various phosphorylation states
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