GANP Isoform GANP: As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores. Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations. Isoform MCM3AP: Binds to and acetylates the replication protein MCM3. Plays a role in the initiation of DNA replication and participates in controls that ensure that DNA replication initiates only once per cell cycle. Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations. Belongs to the SAC3 family. Widely expressed (PubMed:11024281). Up-regulated in germinal center B-cells in tonsils (at protein level) (PubMed:11024281). 2 human isoforms generated by alternative promoter usage have been reported. Note: This description may include information from UniProtKB.
Protein type: Acetyltransferase; Karyopherin
Chromosomal Location of Human Ortholog: 21q22.3
Cellular Component:  cytosol; nuclear membrane; nuclear pore nuclear basket; nucleoplasm; nucleus; transcription export complex 2
Molecular Function:  chromatin binding; H3 histone acetyltransferase activity; histone acetyltransferase activity; histone binding; nucleic acid binding; protein binding
Biological Process:  histone H3 acetylation; nucleosome organization; poly(A)+ mRNA export from nucleus; somatic hypermutation of immunoglobulin genes
Disease: Peripheral Neuropathy, Autosomal Recessive, With Or Without Impaired Intellectual Development
Reference #:  O60318 (UniProtKB)
Alt. Names/Synonyms: 80 kDa MCM3-associated protein; FLJ44336; FLJ45306; GANP; germinal center-associated nuclear protein; Germinal-center associated nuclear protein; KIAA0572; MAP80; MCM3 import protein; MCM3 minichromosome maintenance deficient 3 associated protein; MCM3A; MCM3AP; minichromosome maintenance complex component 3 associated protein; minichromosome maintenance deficient 3-associated protein; Protein GANP
Gene Symbols: MCM3AP
Molecular weight: 218,405 Da
Basal Isoelectric point: 5.99  Predict pI for various phosphorylation states
Select Structure to View Below

GANP

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB