GANP Isoform GANP: As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores. Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations. Isoform MCM3AP: Binds to and acetylates the replication protein MCM3. Plays a role in the initiation of DNA replication and participates in controls that ensure that DNA replication initiates only once per cell cycle. Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations. Belongs to the SAC3 family. Widely expressed (PubMed:11024281). Up-regulated in germinal center B-cells in tonsils (at protein level) (PubMed:11024281). 2 human isoforms generated by alternative promoter usage have been reported. Note: This description may include information from UniProtKB.
Protein type: Acetyltransferase; Karyopherin
Chromosomal Location of Human Ortholog: 10|10 C1
Cellular Component:  cytoplasm; cytosol; nuclear membrane; nuclear pore; nuclear pore nuclear basket; nucleus; transcription export complex 2
Molecular Function:  chromatin binding; H3 histone acetyltransferase activity; histone acetyltransferase activity; histone binding; nucleic acid binding
Biological Process:  immune system process; mRNA export from nucleus; mRNA transport; nucleosome organization; poly(A)+ mRNA export from nucleus; protein transport; somatic hypermutation of immunoglobulin genes
Reference #:  Q9WUU9 (UniProtKB)
Alt. Names/Synonyms: 80 kDa MCM3-associated protein; Ganp; Germinal-center associated nuclear protein; Map80; MCM3A; Mcm3ap; minichromosome maintenance deficient 3 (S. cerevisiae) associated protein; minichromosome maintenance deficient 3-associated protein; mKIAA0572; nuclear protein GANP; Protein GANP
Gene Symbols: Mcm3ap
Molecular weight: 217,362 Da
Basal Isoelectric point: 6.19  Predict pI for various phosphorylation states
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GANP

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene