G-alpha(s) a guanine nucleotide-binding protein of the G12 class of G-alpha proteins. Agonist binding to Gq-coupled receptors may block Akt activation via the release of active G-alpha(q) subunits that inhibit phosphatidylinositol 3-kinase. Heterotrimeric G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G(s); Membrane protein, peripheral; Oncoprotein; Vesicle
Chromosomal Location of Human Ortholog: 20q13.32
Cellular Component:  apical plasma membrane; cytosol; dendrite; membrane
Molecular Function:  adenylate cyclase activator activity; GTP binding; metal ion binding; protein binding
Biological Process:  adenylate cyclase-activating G protein-coupled receptor signaling pathway; bone development; cartilage development; developmental growth; DNA methylation; embryonic cranial skeleton morphogenesis; embryonic hindlimb morphogenesis; endochondral ossification; energy reserve metabolic process; genetic imprinting; multicellular organism growth; platelet aggregation; positive regulation of catalytic activity; positive regulation of cold-induced thermogenesis; positive regulation of osteoblast differentiation; positive regulation of osteoclast differentiation; post-embryonic body morphogenesis; regulation of parathyroid hormone secretion; response to drug; skin development; tissue homeostasis
Disease: Acth-independent Macronodular Adrenal Hyperplasia; Mccune-albright Syndrome; Osseous Heteroplasia, Progressive; Pituitary Adenoma 3, Multiple Types; Pseudohypoparathyroidism, Type Ia; Pseudohypoparathyroidism, Type Ib; Pseudohypoparathyroidism, Type Ic; Pseudopseudohypoparathyroidism
Reference #:  P63092 (UniProtKB)
Alt. Names/Synonyms: Adenylate cyclase-stimulating G alpha protein; AHO; alternative gene product encoded by XL-exon; extra large alphas protein; GNAS; GNAS complex locus; GNAS1; GNAS2; GPSA; GSA; GSP; guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1; guanine nucleotide regulatory protein; Guanine nucleotide-binding protein G(s) subunit alpha isoforms short; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas; MGC33735; NESP; PHP1A; PHP1B; PHP1C; POH; protein ALEX
Gene Symbols: GNAS
Molecular weight: 45,665 Da
Basal Isoelectric point: 5.59  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Microtubule Dynamics  |  Parkinson's Disease  |  Phospholipase Signaling  |  PI3K/Akt Signaling
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein