G-alpha(s) Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. Stimulates the Ras signaling pathway via RAPGEF2. Belongs to the G-alpha family. G(s) subfamily. 1 alternatively spliced human isoform has been reported. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G(s); Membrane protein, peripheral; Oncoprotein; Vesicle
Chromosomal Location of human Ortholog: 20q13.32
Cellular Component:  apical plasma membrane; cytosol; heterotrimeric G-protein complex; membrane
Molecular Function:  adenylate cyclase activator activity; beta-2 adrenergic receptor binding; corticotropin-releasing hormone receptor 1 binding; D1 dopamine receptor binding; G-protein beta/gamma-subunit complex binding; GTP binding; GTPase activity; insulin-like growth factor receptor binding; ionotropic glutamate receptor binding; metal ion binding; mu-type opioid receptor binding; protein binding
Biological Process:  adenylate cyclase-activating dopamine receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway; bone development; developmental growth; platelet aggregation; positive regulation of cold-induced thermogenesis; sensory perception of chemical stimulus
Disease: Acth-independent Macronodular Adrenal Hyperplasia; Desbuquois Dysplasia 2; Mccune-albright Syndrome; Osseous Heteroplasia, Progressive; Pituitary Adenoma 3, Multiple Types; Pseudohypoparathyroidism, Type Ia; Pseudohypoparathyroidism, Type Ib; Pseudohypoparathyroidism, Type Ic; Pseudopseudohypoparathyroidism
Reference #:  P63092 (UniProtKB)
Alt. Names/Synonyms: Adenylate cyclase-stimulating G alpha protein; AHO; alternative gene product encoded by XL-exon; C20orf45; extra large alphas protein; G protein subunit alpha S; G-alpha(s); GNAS; GNAS complex locus; GNAS1; GNAS2; GPSA; GSA; GSP; guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1; guanine nucleotide regulatory protein; Guanine nucleotide-binding protein G(s) subunit alpha isoforms short; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas; MGC33735; NESP; PHP1A; PHP1B; PHP1C; PITA3; POH; protein ALEX; protein GNAS; protein SCG6 (secretogranin VI); SCG6; secretogranin VI; SgVI
Gene Symbols: GNAS
Molecular weight: 45,665 Da
Basal Isoelectric point: 5.59  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Microtubule Dynamics  |  Parkinson's Disease  |  Phospholipase Signaling  |  PI3K/Akt Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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G-alpha(s)
Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  Reactome  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein