SLC25A11 Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism. Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae. Involved in the regulation of apoptosis. Belongs to the mitochondrial carrier (TC 2.A.29) family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 17p13.2
Cellular Component:  integral component of plasma membrane; mitochondrial inner membrane
Biological Process:  alpha-ketoglutarate transport; gluconeogenesis; transmembrane transport
Disease: Paragangliomas 6
Reference #:  Q02978 (UniProtKB)
Alt. Names/Synonyms: M2OM; Mitochondrial 2-oxoglutarate/malate carrier protein; OGC; OGCP; oxoglutarate carrier), member 11; SLC20A4; SLC25A11; solute carrier family 20 (oxoglutarate carrier), member 4; solute carrier family 25 (mitochondrial carrier; Solute carrier family 25 member 11
Gene Symbols: SLC25A11
Molecular weight: 34,062 Da
Basal Isoelectric point: 9.92  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein