SLC25A11 Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism. Belongs to the mitochondrial carrier family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 17p13.2
Cellular Component:  integral component of plasma membrane; mitochondrial inner membrane
Biological Process:  alpha-ketoglutarate transport; gluconeogenesis; transmembrane transport
Reference #:  Q02978 (UniProtKB)
Alt. Names/Synonyms: M2OM; Mitochondrial 2-oxoglutarate/malate carrier protein; OGC; OGCP; oxoglutarate carrier), member 11; SLC20A4; SLC25A11; solute carrier family 20 (oxoglutarate carrier), member 4; solute carrier family 25 (mitochondrial carrier; Solute carrier family 25 member 11
Gene Symbols: SLC25A11
Molecular weight: 34,062 Da
Basal Isoelectric point: 9.92  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein