CDC42 iso1 Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. Facilitates filopodia formation upon DOCK11-activation. Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling. Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups. Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily. 1 alternatively spliced human isoform has been reported. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 1p36.12
Cellular Component:  cytoplasm; cytoplasmic ribonucleoprotein granule; cytosol; dendritic spine; endoplasmic reticulum membrane; filopodium; Golgi membrane; Golgi transport complex; membrane; midbody; mitotic spindle; neuron projection; neuronal cell body; plasma membrane; protein-containing complex; spindle midzone
Molecular Function:  apolipoprotein A-I receptor binding; GBD domain binding; GTP binding; GTPase activity; identical protein binding; protein binding; protein kinase binding; thioesterase binding; ubiquitin protein ligase activity
Biological Process:  actin cytoskeleton organization; actin filament organization; blood coagulation; cell junction assembly; dendritic spine morphogenesis; ephrin receptor signaling pathway; establishment of epithelial cell apical/basal polarity; establishment of Golgi localization; establishment or maintenance of cell polarity; Fc-gamma receptor signaling pathway involved in phagocytosis; Golgi organization; integrin-mediated signaling pathway; interleukin-12-mediated signaling pathway; macrophage differentiation; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of protein complex assembly; neuropilin signaling pathway; organelle transport along microtubule; phagocytosis, engulfment; positive regulation of actin cytoskeleton reorganization; positive regulation of cell growth; positive regulation of cytokinesis; positive regulation of filopodium assembly; positive regulation of lamellipodium assembly; positive regulation of muscle cell differentiation; positive regulation of pseudopodium assembly; positive regulation of stress fiber assembly; positive regulation of substrate adhesion-dependent cell spreading; protein ubiquitination; regulation of attachment of spindle microtubules to kinetochore; regulation of filopodium assembly; regulation of lamellipodium assembly; regulation of small GTPase mediated signal transduction; regulation of stress fiber assembly; T cell costimulation; vascular endothelial growth factor receptor signaling pathway; viral RNA genome replication; Wnt signaling pathway, planar cell polarity pathway
Disease: Takenouchi-kosaki Syndrome
Reference #:  P60953-1 (UniProtKB)
Alt. Names/Synonyms: CDC42; CDC42 iso1; CDC42Hs; Cell division control protein 42 homolog; cell division cycle 42; cell division cycle 42 (GTP binding protein, 25kDa); dJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD)); dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD)); G25K; G25K GTP-binding protein; growth-regulating protein; GTP binding protein, 25kDa; GTP-binding protein, 25kD; small GTP binding protein CDC42; TKS
Gene Symbols: CDC42
Molecular weight: 21,311 Da
Basal Isoelectric point: 5.76  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Microtubule Dynamics  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-ß Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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CDC42 iso1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein