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ZNF350
Transcriptional repressor. Binds to a specific sequence, 5'-GGGxxxCAGxxxTTT-3', within GADD45 intron 3. Belongs to the krueppel C2H2-type zinc-finger protein family. Widely expressed. Note: This description may include information from UniProtKB.
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| Protein type: C2H2-type zinc finger protein; Transcription factor |
| Chromosomal Location of human Ortholog: 19q13.41 |
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Cellular Component:
nuclear body; nuclear matrix; nucleoplasm; nucleus; transcription repressor complex
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Molecular Function:
DNA binding; DNA-binding transcription factor activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; metal ion binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
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Biological Process:
negative regulation of DNA-templated transcription; negative regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II
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Reference #:
Q9GZX5
(UniProtKB)
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Alt. Names/Synonyms: KRAB zinc finger protein ZFQR; ZBRK1; ZFQR; Zinc finger and BRCA1-interacting protein with a KRAB domain 1; Zinc finger protein 350; Zinc finger protein ZBRK1; zinc-finger protein ZBRK1; ZN350; ZNF350
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Gene Symbols: ZNF350
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Molecular weight:
60,011 Da
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Basal Isoelectric point:
8.92
Predict pI for various phosphorylation states
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