ATP2B3 This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily. Highly expressed in the cerebellum, particulary in the presynaptic terminals of parallel fibers-Purkinje neurons. Isoform XE and isoform XB are the most abundant isoforms and are detected at low levels in brain and fetal skeletal muscle. The other isoforms are only found at lower levels and not in fetal tissues. 8 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel
Chromosomal Location of Human Ortholog: Xq28
Cellular Component:  GABA-ergic synapse; glutamatergic synapse; Golgi apparatus; plasma membrane; presynapse
Molecular Function:  ATP binding; calcium ion transmembrane transporter activity; calcium-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration; calmodulin binding; metal ion binding; protein binding
Biological Process:  ATP hydrolysis coupled cation transmembrane transport; calcium ion export across plasma membrane; calcium ion transmembrane transport; ion transmembrane transport; regulation of cardiac conduction; regulation of cytosolic calcium ion concentration; regulation of presynaptic cytosolic calcium ion concentration
Disease: Spinocerebellar Ataxia, X-linked 1
Reference #:  Q16720 (UniProtKB)
Alt. Names/Synonyms: AT2B3; ATP2B3; ATPase plasma membrane Ca2+ transporting 3; ATPase, Ca++ transporting, plasma membrane 3; CFAP39; cilia and flagella associated protein 39; CLA2; OPCA; plasma membrane calcium ATPase; Plasma membrane calcium ATPase isoform 3; plasma membrane calcium pump; Plasma membrane calcium pump isoform 3; Plasma membrane calcium-transporting ATPase 3; PMCA3; PMCA3a; SCAX1
Gene Symbols: ATP2B3
Molecular weight: 134,197 Da
Basal Isoelectric point: 5.45  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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