Myt1 Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.1; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor); WEE family
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component:  cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi apparatus; Golgi membrane; nucleolus; nucleoplasm; nucleus
Molecular Function:  ATP binding; kinase activity; metal ion binding; protein binding; protein serine/threonine kinase activity
Biological Process:  G2/M transition of mitotic cell cycle; mitotic cell cycle; negative regulation of phosphatase activity; protein phosphorylation; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of mitotic nuclear division
Reference #:  Q99640 (UniProtKB)
Alt. Names/Synonyms: DKFZp547K1610; FLJ20093; Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase; MYT1; Myt1 kinase; PKMYT1; PMYT1; protein kinase Myt1; protein kinase, membrane associated tyrosine/threonine 1
Gene Symbols: PKMYT1
Molecular weight: 54,521 Da
Basal Isoelectric point: 6.48  Predict pI for various phosphorylation states
CST Pathways:  G2/M DNA Damage Checkpoint  |  Growth And Differentiation Control by MAPKs  |  PI3K/Akt Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Myt1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB