ADM
AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels. Belongs to the adrenomedullin family. Highest levels found in pheochromocytoma and adrenal medulla. Also found in lung, ventricle and kidney tissues. Note: This description may include information from UniProtKB.
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Protein type: Secreted; Secreted, signal peptide |
Chromosomal Location of mouse Ortholog: 7 E3|7 57.7 cM |
Cellular Component:
cytoplasm; extracellular region; extracellular space
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Molecular Function:
adrenomedullin receptor binding; hormone activity
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Biological Process:
adenylate cyclase-activating G protein-coupled receptor signaling pathway; adrenomedullin receptor signaling pathway; amylin receptor signaling pathway; androgen metabolic process; antibacterial humoral response; antimicrobial humoral immune response mediated by antimicrobial peptide; branching involved in labyrinthine layer morphogenesis; cell population proliferation; defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; developmental growth; G protein-coupled receptor internalization; heart development; negative regulation of cell population proliferation; negative regulation of vascular permeability; negative regulation of vasoconstriction; neural tube closure; neuron projection regeneration; positive regulation of angiogenesis; positive regulation of apoptotic process; positive regulation of cell population proliferation; positive regulation of cytosolic calcium ion concentration; positive regulation of heart rate; positive regulation of vasculogenesis; receptor internalization; regulation of systemic arterial blood pressure; regulation of the force of heart contraction; regulation of urine volume; response to lipopolysaccharide; spongiotrophoblast layer development; vascular associated smooth muscle cell development; vasculogenesis
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Reference #:
P97297
(UniProtKB)
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Alt. Names/Synonyms: ADM; ADML; Adrenomedullin; AM; PAMP; Pro-adrenomedullin; Proadrenomedullin N-20 terminal peptide; ProAM N-terminal 20 peptide; ProAM-N20
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Gene Symbols: Adm
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Molecular weight:
20,750 Da
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Basal Isoelectric point:
10.35
Predict pI for various phosphorylation states
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