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DLK
Part of a non-canonical MAPK signaling pathway. Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1. May be an activator of the JNK/SAPK pathway. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. Highly expressed in brain and kidney. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.11.25; Kinase, protein; LZK subfamily; MLK family; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group |
| Chromosomal Location of mouse Ortholog: 15|15 F3 |
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Cellular Component:
axon; cytoplasm; cytosol; growth cone; membrane; plasma membrane
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Molecular Function:
ATP binding; JUN kinase kinase kinase activity; kinase activity; MAP kinase kinase kinase activity; nucleotide binding; protein homodimerization activity; protein kinase activity; protein kinase binding; protein serine/threonine kinase activator activity; protein serine/threonine kinase activity; transferase activity
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Biological Process:
JNK cascade; negative regulation of motor neuron apoptotic process; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of DNA-templated transcription; positive regulation of ERK1 and ERK2 cascade; positive regulation of JUN kinase activity; positive regulation of protein kinase activity; post-translational protein modification; protein autophosphorylation; protein phosphorylation
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Reference #:
Q60700
(UniProtKB)
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Alt. Names/Synonyms: DLK; Dual leucine zipper bearing kinase; Leucine-zipper protein kinase; M3K12; Map3k12; MAPK-upstream kinase; mitogen activated protein kinase kinase kinase 12; Mitogen-activated protein kinase kinase kinase 12; Mixed lineage kinase; MUK; zipper (leucine) protein kinase; ZPK
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Gene Symbols: Map3k12
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Molecular weight:
96,084 Da
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Basal Isoelectric point:
5.86
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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B Cell Receptor Signaling
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Regulation of P38 MAPKs
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SAPK/JNK Signaling Cascades
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