PLK3
Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/TP53, p73/TP73, PTEN, TOP2A and VRK1. Involved in cell cycle regulation: required for entry into S phase and cytokinesis. Phosphorylates BCL2L1, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Plays a key role in response to stress: rapidly activated upon stress stimulation, such as ionizing radiation, reactive oxygen species (ROS), hyperosmotic stress, UV irradiation and hypoxia. Involved in DNA damage response and G1/S transition checkpoint by phosphorylating CDC25A, p53/TP53 and p73/TP73. Phosphorylates p53/TP53 in response to reactive oxygen species (ROS), thereby promoting p53/TP53-mediated apoptosis. Phosphorylates CHEK2 in response to DNA damage, promoting the G2/M transition checkpoint. Phosphorylates the transcription factor p73/TP73 in response to DNA damage, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates HIF1A and JUN is response to hypoxia. Phosphorylates ATF2 following hyperosmotic stress in corneal epithelium. Also involved in Golgi disassembly during the cell cycle: part of a MEK1/MAP2K1-dependent pathway that induces Golgi fragmentation during mitosis by mediating phosphorylation of VRK1. May participate in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation, via its interaction with CIB1. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. Transcripts are highly detected in placenta, lung, followed by skeletal muscle, heart, pancreas, ovaries and kidney and weakly detected in liver and brain. May have a short half-live. In cells of hematopoietic origin, strongly and exclusively detected in terminally differentiated macrophages. Transcript expression appears to be down-regulated in primary lung tumor. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.21; Kinase, protein; Nucleolus; Other group; PLK family; PLK2 subfamily; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Molecular Function: ATP binding; p53 binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity
Biological Process: apoptotic process; cytoplasmic microtubule organization; DNA damage response; G1/S transition of mitotic cell cycle; Golgi disassembly; mitotic G1/S transition checkpoint signaling; mitotic spindle organization; negative regulation of apoptotic process; negative regulation of transcription by RNA polymerase II; positive regulation of chaperone-mediated autophagy; positive regulation of intracellular protein transport; positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia; protein kinase B signaling; protein phosphorylation; regulation of cell division; regulation of cytokinesis; regulation of long-term neuronal synaptic plasticity; regulation of synaptic plasticity; response to osmotic stress; response to radiation; response to reactive oxygen species
