PLK3 Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/TP53, p73/TP73, PTEN, TOP2A and VRK1. Involved in cell cycle regulation: required for entry into S phase and cytokinesis. Phosphorylates BCL2L1, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Plays a key role in response to stress: rapidly activated upon stress stimulation, such as ionizing radiation, reactive oxygen species (ROS), hyperosmotic stress, UV irradiation and hypoxia. Involved in DNA damage response and G1/S transition checkpoint by phosphorylating CDC25A, p53/TP53 and p73/TP73. Phosphorylates p53/TP53 in response to reactive oxygen species (ROS), thereby promoting p53/TP53-mediated apoptosis. Phosphorylates CHEK2 in response to DNA damage, promoting the G2/M transition checkpoint. Phosphorylates the transcription factor p73/TP73 in response to DNA damage, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates HIF1A and JUN is response to hypoxia. Phosphorylates ATF2 following hyperosmotic stress in corneal epithelium. Also involved in Golgi disassembly during the cell cycle: part of a MEK1/MAP2K1-dependent pathway that induces Golgi fragmentation during mitosis by mediating phosphorylation of VRK1. May participate in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation, via its interaction with CIB1. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. Transcripts are highly detected in placenta, lung, followed by skeletal muscle, heart, pancreas, ovaries and kidney and weakly detected in liver and brain. May have a short half-live. In cells of hematopoietic origin, strongly and exclusively detected in terminally differentiated macrophages. Transcript expression appears to be down-regulated in primary lung tumor. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.21; Kinase, protein; Nucleolus; Other group; PLK family; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 5q36
Cellular Component:  centrosome; chromatin; cytoplasm; dendrite; Golgi stack; neuronal cell body; nucleolus; nucleus; spindle pole
Molecular Function:  ATP binding; p53 binding; protein binding; protein kinase activity; protein serine/threonine kinase activity
Biological Process:  apoptotic process; cellular response to DNA damage stimulus; cytoplasmic microtubule organization; G1/S transition of mitotic cell cycle; Golgi disassembly; mitotic cell cycle; mitotic G1/S transition checkpoint; negative regulation of apoptotic process; negative regulation of transcription by RNA polymerase II; positive regulation of chaperone-mediated autophagy; positive regulation of intracellular protein transport; positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia; protein kinase B signaling; protein phosphorylation; regulation of cell division; regulation of cytokinesis; regulation of long-term neuronal synaptic plasticity; regulation of synaptic plasticity; response to osmotic stress; response to radiation; response to reactive oxygen species
Reference #:  Q9R011 (UniProtKB)
Alt. Names/Synonyms: Cnk; cytokine inducible kinase; Cytokine-inducible serine/threonine-protein kinase; FGF-inducible kinase; Fnk; PLK-3; Plk3; Polo-like kinase 3; polo-like kinase 3 (Drosophila); serine-threonine kinase; Serine/threonine-protein kinase PLK3
Gene Symbols: Plk3
Molecular weight: 71,768 Da
Basal Isoelectric point: 9.26  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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PLK3

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Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene