CLK4 Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily. Expressed in liver, kidney, heart, muscle, brain and endothelial cells. Note: This description may include information from UniProtKB.
Protein type: CLK family; CMGC group; EC 2.7.12.1; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor)
Chromosomal Location of Human Ortholog: 11|11 B1.3
Cellular Component:  nucleus
Molecular Function:  ATP binding; kinase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity; transferase activity
Biological Process:  peptidyl-tyrosine phosphorylation; phosphorylation; protein autophosphorylation; protein phosphorylation; regulation of RNA splicing
Reference #:  O35493 (UniProtKB)
Alt. Names/Synonyms: AI987988; C85119; CDC like kinase 4; CDC-like kinase 4; Clk4; Dual specificity protein kinase CLK4; OTTMUSP00000005757
Gene Symbols: Clk4
Molecular weight: 57,345 Da
Basal Isoelectric point: 8.84  Predict pI for various phosphorylation states
Select Structure to View Below

CLK4

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene