CDC7 Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC7 subfamily. 1 alternatively spliced human isoform has been reported. Note: This description may include information from UniProtKB.
Protein type: CDC7 family; EC; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of mouse Ortholog: 5|5 E5
Cellular Component:  cytoplasm; intercellular bridge; mitotic spindle; nucleoplasm; nucleus
Molecular Function:  ATP binding; kinase activity; metal ion binding; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  cell cycle; cell cycle phase transition; cell division; double-strand break repair via break-induced replication; peptidyl-serine phosphorylation; phosphorylation; positive regulation of cell population proliferation; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of nuclear cell cycle DNA replication; protein phosphorylation; signal transduction
Reference #:  Q9Z0H0 (UniProtKB)
Alt. Names/Synonyms: AI597260; Cdc7; CDC7-related kinase; Cdc7l; Cdc7l1; cell division cycle 7 (S. cerevisiae); cell division cycle 7-like 1; Cell division cycle 7-related protein kinase; MGC91067; muCdc7
Gene Symbols: Cdc7
Molecular weight: 62,770 Da
Basal Isoelectric point: 8.87  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene