CDC7
Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC7 subfamily. 1 alternatively spliced human isoform has been reported. Note: This description may include information from UniProtKB.
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Protein type: CDC7 family; EC 2.7.11.1; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) |
Chromosomal Location of mouse Ortholog: 5|5 E5 |
Cellular Component:
cytoplasm; intercellular bridge; mitotic spindle; nucleoplasm; nucleus
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Molecular Function:
ATP binding; kinase activity; metal ion binding; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
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Biological Process:
cell cycle; cell cycle phase transition; cell division; double-strand break repair via break-induced replication; peptidyl-serine phosphorylation; phosphorylation; positive regulation of cell population proliferation; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of nuclear cell cycle DNA replication; protein phosphorylation; signal transduction
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Reference #:
Q9Z0H0
(UniProtKB)
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Alt. Names/Synonyms: AI597260; Cdc7; CDC7-related kinase; Cdc7l; Cdc7l1; cell division cycle 7 (S. cerevisiae); cell division cycle 7-like 1; Cell division cycle 7-related protein kinase; MGC91067; muCdc7
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Gene Symbols: Cdc7
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Molecular weight:
62,770 Da
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Basal Isoelectric point:
8.87
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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