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CASK
Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. Belongs to the MAGUK family. Ubiquitous. Expression is significantly greater in brain relative to kidney, lung, and liver and in fetal brain and kidney relative to lung and liver. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; CAMK group; CASK family; EC 2.7.11.1; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) |
| Chromosomal Location of mouse Ortholog: X A1.1|X 8.43 cM |
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Cellular Component:
apical dendrite; basement membrane; basolateral plasma membrane; cell-cell junction; ciliary membrane; cytoplasm; cytosol; dendrite; membrane; neuronal cell body; nuclear lamina; nuclear matrix; nucleolus; nucleus; perinuclear region of cytoplasm; plasma membrane; podocyte foot; presynaptic membrane; protein-containing complex; Schaffer collateral - CA1 synapse; synapse; synaptic membrane; vesicle
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Molecular Function:
ATP binding; calmodulin binding; kinase activity; neurexin family protein binding; nucleotide binding; PDZ domain binding; protein binding; protein kinase activity; protein kinase C binding; protein serine/threonine kinase activity; protein-containing complex binding; signaling receptor binding; transferase activity
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Biological Process:
calcium ion import; establishment of localization in cell; negative regulation of cell-matrix adhesion; negative regulation of cellular response to growth factor stimulus; negative regulation of keratinocyte proliferation; negative regulation of wound healing; phosphorylation; positive regulation of calcium ion import; positive regulation of dendritic spine morphogenesis; positive regulation of insulin secretion; positive regulation of transcription by RNA polymerase II; protein localization to plasma membrane; protein phosphorylation; regulation of neurotransmitter secretion; regulation of synaptic vesicle exocytosis; regulation of transcription by RNA polymerase II
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Reference #:
O70589
(UniProtKB)
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Alt. Names/Synonyms: Calcium/calmodulin-dependent serine protein kinase; calcium/calmodulin-dependent serine protein kinase (MAGUK family); Cask; CSKP; DXP; DXPri1; DXRi; DXRib1; LIN-2; MGC7449; mLi; mLin-2; Pals3; Peripheral plasma membrane protein CASK
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Gene Symbols: Cask
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Molecular weight:
105,109 Da
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Basal Isoelectric point:
5.99
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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