BUB1 a mitotic-checkpoint protein kinase of the BUB family. Autophosphorylated when the cells enters mitosis. Kinetochore localization is required for normal mitotic timing and checkpoint response to spindle damage. High expression in testis and thymus, less in colon, spleen, lung and small intestine. Expressed in fetal thymus, bone marrow, heart, liver, spleen and thymus. Expression is associated with cells/tissues with a high mitotic index. LOF mutations seen in two colon cancer cell lines exhibiting chromosomal instability, in several leukemias and lymphomas, and in a pancreatic cancer cell line. BUB1 functions in mitotic spindle assembly, and may cause chromosomal instability. In mouse BRCA2 knockouts, mutations in BUB1 and BUBR1 are frequently seen in the resulting tumors. BUB1 and BUBR1 are overexpressed, but not mutated, in many gastric cancers. Note: This description may include information from UniProtKB.
Protein type: BUB family; Cell cycle regulation; EC; Kinase, protein; Other group; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 2 F1|2 62.1 cM
Cellular Component:  chromosome; chromosome, centromeric region; condensed chromosome kinetochore; condensed nuclear chromosome kinetochore; condensed nuclear chromosome outer kinetochore; condensed nuclear chromosome, centromeric region; cytosol; kinetochore; nucleoplasm; nucleus
Molecular Function:  ATP binding; kinase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  apoptotic process; cell cycle; cell division; chromosome segregation; meiotic sister chromatid cohesion, centromeric; mitotic spindle assembly checkpoint; phosphorylation; positive regulation of intrinsic apoptotic signaling pathway; regulation of chromosome segregation; regulation of sister chromatid cohesion
Reference #:  O08901 (UniProtKB)
Alt. Names/Synonyms: AL022991; Bub1; BUB1A; budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae); C80208; D2Xrf87; mBUB1; Mitotic checkpoint serine/threonine-protein kinase BUB1
Gene Symbols: Bub1
Molecular weight: 119,563 Da
Basal Isoelectric point: 5.74  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs
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Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene