APAF Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis. Ubiquitous. Highest levels of expression in adult spleen and peripheral blood leukocytes, and in fetal brain, kidney and lung. Isoform 1 is expressed in heart, kidney and liver. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Apoptosis
Chromosomal Location of Human Ortholog: 10 C2|10 45.47 cM
Cellular Component:  apoptosome; cytoplasm; cytosol; nucleus; protein-containing complex
Molecular Function:  ADP binding; ATP binding; cysteine-type endopeptidase activator activity involved in apoptotic process; heat shock protein binding; identical protein binding; nucleotide binding
Biological Process:  activation of cysteine-type endopeptidase activity involved in apoptotic process; activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; apoptotic process; apoptotic signaling pathway; brain development; cardiac muscle cell apoptotic process; cellular response to transforming growth factor beta stimulus; forebrain development; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; multicellular organism development; neural tube closure; neuron apoptotic process; positive regulation of apoptotic signaling pathway; protein homooligomerization; regulation of apoptotic DNA fragmentation; regulation of apoptotic process
Reference #:  O88879 (UniProtKB)
Alt. Names/Synonyms: 6230400I06Rik; APAF; APAF-1; Apaf1; Apaf1l; apoptotic peptidase activating factor 1; apoptotic protease activating factor 1; Apoptotic protease-activating factor 1; fog; forebrain overgrowth; KIAA0413; mKIAA0413
Gene Symbols: Apaf1
Molecular weight: 141,003 Da
Basal Isoelectric point: 5.98  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene