HERC1 Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Widely expressed. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; EC; GEF; GEF, ARF; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of human Ortholog: 15q22.31
Cellular Component:  cytoplasm; cytosol; Golgi apparatus; membrane
Molecular Function:  ARF guanyl-nucleotide exchange factor activity; ubiquitin-protein transferase activity
Biological Process:  cerebellar Purkinje cell differentiation; negative regulation of autophagy; neuromuscular process controlling balance; neuron projection development; protein ubiquitination
Disease: Macrocephaly, Dysmorphic Facies, And Psychomotor Retardation
Reference #:  Q15751 (UniProtKB)
Alt. Names/Synonyms: guanine nucleotide exchange factor p532; hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1; HECT and RLD domain containing E3 ubiquitin protein ligase family member 1; hect domain and RCC1-like domain 1; HECT domain and RCC1-like domain-containing protein 1; HECT-type E3 ubiquitin transferase HERC1; HERC1; MDFPMR; p532; p619; Probable E3 ubiquitin-protein ligase HERC1
Gene Symbols: HERC1
Molecular weight: 532,228 Da
Basal Isoelectric point: 5.69  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB