nAChRA4 After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-4/CHRNA4 sub-subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.
Chromosomal Location of mouse Ortholog: 2 H4|2 103.54 cM
Cellular Component:  acetylcholine-gated channel complex; cholinergic synapse; dendrite; dopaminergic synapse; external side of plasma membrane; membrane; neuron projection; neuronal cell body; plasma membrane; postsynaptic membrane; postsynaptic specialization membrane; presynapse; presynaptic membrane; protein-containing complex; synapse
Molecular Function:  acetylcholine binding; acetylcholine receptor activity; acetylcholine-gated monoatomic cation-selective channel activity; extracellular ligand-gated monoatomic ion channel activity; heterocyclic compound binding; monoatomic ion channel activity; protein binding; protein-containing complex binding; quaternary ammonium group binding; transmembrane signaling receptor activity; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
Biological Process:  acetylcholine receptor signaling pathway; B cell activation; behavioral response to nicotine; calcium ion transport; cognition; DNA repair; exploration behavior; inhibitory postsynaptic potential; locomotory behavior; membrane depolarization; monoatomic ion transmembrane transport; monoatomic ion transport; nervous system process; neuronal action potential; presynaptic modulation of chemical synaptic transmission; regulation of acetylcholine-gated cation channel activity; regulation of dopamine secretion; regulation of membrane potential; respiratory gaseous exchange by respiratory system; response to acetylcholine; response to hypoxia; response to nicotine; response to oxidative stress; sensory perception of pain; signal transduction; synaptic transmission, cholinergic
Reference #:  O70174 (UniProtKB)
Alt. Names/Synonyms: a4 nicotinic receptor; acetylcholine receptor alpha 4 neural; acetylcholine receptor, neuronal, nicotinic, alpha-4 subunit; ACHA4; Acr; Acra-4; Acra4; alpha4 nAChR; alpha4-nAChR; cholinergic receptor, nicotinic, alpha polypeptide 4; Chrna4; EBN1; ENFL1; nAChRA4; Neuronal acetylcholine receptor subunit alpha-4; OTTMUSP00000017643
Gene Symbols: Chrna4
Molecular weight: 70,305 Da
Basal Isoelectric point: 6.93  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein