PRC1 Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression. Belongs to the MAP65/ASE1 family. Overexpressed in bladder cancer cells (PubMed:17409436). 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Cytoskeletal; Microtubule-binding; Motility/polarity/chemotaxis
Chromosomal Location of mouse Ortholog: 7 D2|7 45.62 cM
Cellular Component:  contractile ring; cytoplasm; cytoskeleton; microtubule; midbody; nucleus; spindle
Molecular Function:  identical protein binding; kinesin binding; microtubule binding; protein kinase binding
Biological Process:  cell cycle; cell division; microtubule bundle formation; microtubule cytoskeleton organization; positive regulation of cell proliferation; regulation of cytokinesis
Reference #:  Q99K43 (UniProtKB)
Alt. Names/Synonyms: D7Ertd348; D7Ertd348e; MGC6745; Prc1; Protein regulator of cytokinesis 1
Gene Symbols: Prc1
Molecular weight: 70,290 Da
Basal Isoelectric point: 7.5  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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PRC1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene