IREM-1 Acts as an inhibitory receptor for myeloid cells and mast cells. Inhibits osteoclast formation. Belongs to the CD300 family. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 17q25.1
Cellular Component:  integral component of membrane; plasma membrane
Molecular Function:  interleukin-4 receptor binding; phosphatidylserine binding
Biological Process:  negative regulation of mast cell activation; negative regulation of MyD88-dependent toll-like receptor signaling pathway; regulation of immune response
Reference #:  Q8TDQ1 (UniProtKB)
Alt. Names/Synonyms: CD300 antigen like family member F; CD300 antigen-like family member F; CD300 molecule like family member f; CD300 molecule-like family member f; CD300F; CD300LF; CLM-1; CLM1; CMRF35-like molecule 1; IGSF13; Immune receptor expressed on myeloid cells 1; immunoglobin superfamily member 13; Immunoglobulin superfamily member 13; inhibitory receptor IREM1; IREM-1; IREM1; NK inhibitory receptor; NKIR
Gene Symbols: CD300LF
Molecular weight: 32,335 Da
Basal Isoelectric point: 5.45  Predict pI for various phosphorylation states
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IREM-1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene