PAK2 a protein kinase of the STE20 family. Critical effector linking RhoGTPases to cytoskeleton reorganization and nuclear signaling. Activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; PAKA subfamily; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family
Chromosomal Location of Human Ortholog: 11q22
Cellular Component:  cytoplasm; cytosol; glutamatergic synapse; membrane; nucleus; perinuclear region of cytoplasm; postsynaptic density; secretory granule
Molecular Function:  ATP binding; identical protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; protein tyrosine kinase activator activity; Rac GTPase binding; small GTPase binding
Biological Process:  activation of protein kinase activity; cardiac muscle hypertrophy; cell migration; cellular response to organic cyclic compound; cellular response to transforming growth factor beta stimulus; dendritic spine development; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis; peptidyl-serine phosphorylation; phosphorylation; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of peptidyl-tyrosine phosphorylation; protein autophosphorylation; protein phosphorylation; regulation of MAPK cascade; signal transduction by protein phosphorylation; stress-activated protein kinase signaling cascade
Reference #:  Q64303 (UniProtKB)
Alt. Names/Synonyms: Gamma-PAK; p21 (CDKN1A)-activated kinase 2; p21 protein (Cdc42/Rac)-activated kinase 2; p21-activated kinase 2; PAK-2; PAK-2p27; PAK-2p34; Pak2; Serine/threonine-protein kinase PAK 2
Gene Symbols: Pak2
Molecular weight: 57,960 Da
Basal Isoelectric point: 5.57  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs  |  Microtubule Dynamics  |  TGF-ß Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene