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PIGP
Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. Belongs to the PIGP family. Ubiquitous. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.4.1.198; Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Membrane protein, integral; Membrane protein, multi-pass; Transferase |
| Chromosomal Location of human Ortholog: 21q22.13 |
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Cellular Component:
endoplasmic reticulum; endoplasmic reticulum membrane; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex
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Molecular Function:
phosphatidylinositol N-acetylglucosaminyltransferase activity; protein binding; UDP-glycosyltransferase activity
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Biological Process:
GPI anchor biosynthetic process
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Disease: Epileptic Encephalopathy, Early Infantile, 55
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Reference #:
P57054
(UniProtKB)
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Alt. Names/Synonyms: DCRC; DCRC-S; Down syndrome critical region gene 5; Down syndrome critical region protein 5; Down syndrome critical region protein C; DSCR5; DSCRC; DSRC; EIEE55; phosphatidylinositol glycan anchor biosynthesis class P; phosphatidylinositol glycan anchor biosynthesis, class P; phosphatidylinositol glycan, class P; Phosphatidylinositol N-acetylglucosaminyltransferase subunit P; Phosphatidylinositol-glycan biosynthesis class P protein; phosphatidylinositol-n-acetylglucosaminyltranferase subunit; PIG-P; PIGP
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Gene Symbols: PIGP
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Molecular weight:
18,089 Da
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Basal Isoelectric point:
8.8
Predict pI for various phosphorylation states
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