ERC2 Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 14 A3|14 16.51 cM
Cellular Component:  cell junction; cytoplasm; cytoskeleton; GABA-ergic synapse; glutamatergic synapse; Golgi-associated vesicle; growth cone; membrane; neuron projection; neuronal cell body; postsynaptic density; presynaptic active zone; presynaptic active zone cytoplasmic component; presynaptic membrane; protein-containing complex; synapse; terminal bouton
Molecular Function:  PDZ domain binding; protein binding; protein-containing complex binding; structural constituent of presynaptic active zone
Biological Process:  synaptic vesicle priming
Reference #:  Q6PH08 (UniProtKB)
Alt. Names/Synonyms: 6430531D06; CAST; CAST1; CAST1/ERC2; CAZ-associated structural protein 1; D14Ertd171; D14Ertd171e; ELKS; ELKS/RAB6-interacting/CAST family member 2; ELKS2alpha; ERC protein 2; Erc2; Kiaa0378
Gene Symbols: Erc2
Molecular weight: 110,639 Da
Basal Isoelectric point: 6.55  Predict pI for various phosphorylation states
CST Pathways:  NF-kB Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene