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p21Cip1
May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding. Belongs to the CDI family. Expressed in all adult tissues, with 5-fold lower levels observed in the brain. Note: This description may include information from UniProtKB.
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| Protein type: Cell cycle regulation; Inhibitor |
| Chromosomal Location of mouse Ortholog: 17 A3.3|17 15.12 cM |
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Cellular Component:
cyclin-dependent protein kinase holoenzyme complex; cytoplasm; cytosol; nuclear body; nucleolus; nucleoplasm; nucleus; PCNA-p21 complex; perinuclear region of cytoplasm; protein-containing complex
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Molecular Function:
cyclin binding; cyclin-dependent protein kinase activating kinase activity; cyclin-dependent protein serine/threonine kinase inhibitor activity; metal ion binding; molecular function activator activity; molecular function inhibitor activity; protein binding; protein kinase binding; protein kinase inhibitor activity; protein sequestering activity; protein-containing complex binding; ubiquitin protein ligase binding
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Biological Process:
cell cycle; cellular response to amino acid starvation; cellular response to extracellular stimulus; cellular response to gamma radiation; cellular response to ionizing radiation; cellular response to UV-B; cellular senescence; DNA damage response; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; epidermis development; heart development; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; keratinocyte differentiation; keratinocyte proliferation; mitotic G2 DNA damage checkpoint signaling; negative regulation of apoptotic process; negative regulation of cardiac muscle tissue regeneration; negative regulation of cell growth; negative regulation of cell population proliferation; negative regulation of cyclin-dependent protein kinase activity; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of DNA biosynthetic process; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of gene expression; negative regulation of phosphorylation; negative regulation of protein binding; negative regulation of vascular associated smooth muscle cell proliferation; oncogene-induced cell senescence; positive regulation of B cell proliferation; positive regulation of fibroblast proliferation; positive regulation of programmed cell death; positive regulation of protein kinase activity; positive regulation of reactive oxygen species metabolic process; protein import into nucleus; regulation of cell cycle; regulation of cell cycle G1/S phase transition; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of DNA biosynthetic process; regulation of G1/S transition of mitotic cell cycle; regulation of G2/M transition of mitotic cell cycle; regulation of mitotic cell cycle; response to UV; signal transduction by p53 class mediator; tissue regeneration; wound healing
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Reference #:
P39689
(UniProtKB)
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Alt. Names/Synonyms: CAP; CAP20; CDK; CDK-interacting protein 1; CDKI; Cdkn; Cdkn1; Cdkn1a; CDN1A; Cip1; Cyclin-dependent kinase inhibitor 1; cyclin-dependent kinase inhibitor 1A (P21); mda; mda6; Melanoma differentiation-associated protein; p21; p21<WAF1/CIP1>; p21C; p21Cip1; p21W; p21WAF; SDI1; Waf; Waf1
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Gene Symbols: Cdkn1a
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Molecular weight:
17,785 Da
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Basal Isoelectric point:
9.21
Predict pI for various phosphorylation states
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CST Pathways:
AMPK Signaling
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G1/S Checkpoint
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G2/M DNA Damage Checkpoint
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PI3K/Akt Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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