PXN Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Belongs to the paxillin family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 5 F|5 56.1 cM
Cellular Component:  adherens junction; cell junction; cell leading edge; cytoplasm; cytoskeleton; cytosol; focal adhesion; lamellipodium; plasma membrane; stress fiber
Molecular Function:  beta-catenin binding; BH4 domain binding; integrin binding; metal ion binding; neuropilin binding; protein binding; protein kinase binding; protein phosphatase binding; protein-containing complex binding; receptor signaling complex scaffold activity; transcription coregulator activity; ubiquitin protein ligase binding; vinculin binding
Biological Process:  activation of MAPK activity; branching morphogenesis of an epithelial tube; cell adhesion; cell-matrix adhesion; cytoskeleton organization; endothelial cell migration; focal adhesion assembly; growth hormone receptor signaling pathway; integrin-mediated signaling pathway; lamellipodium assembly; peptidyl-tyrosine phosphorylation; positive regulation of angiogenesis; positive regulation of protein kinase activity; positive regulation of stress fiber assembly; regulation of cell shape; response to peptide; substrate adhesion-dependent cell spreading; transforming growth factor beta receptor signaling pathway
Reference #:  Q8VI36 (UniProtKB)
Alt. Names/Synonyms: AW108311; AW123232; OTTMUSP00000015574; OTTMUSP00000015575; Pax; PAXI; Paxillin; Pxn
Gene Symbols: Pxn
Molecular weight: 64,476 Da
Basal Isoelectric point: 5.67  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PXN

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene