PXN iso2 a multi-domain cytoskeletal protein involved in actin-membrane attachment that localizes primarily to focal adhesion sites to the extracellular matrix. Phosphorylated by focal adhesion kinase (FAK) and is a component of integrin signaling. Its phosphorylation provides docking sites for recruitment of signaling molecules to focal adhesions. Binds in vitro to vinculin as well as to the SH3 domain of c-SRC and, when tyrosine phosphorylated, to the Crk SH2 domain. Interacts with GIT1, NUDT16L1/SDOS, PARVA and TGFB1I1. Component of cytoplasmic complexes, which also contain GIT1, ARHGEF6 and PAK1. Binds DDEF2. Interacts with unphosphorylated ITGA4. Interacts with RNF5.Three alternatively-spliced isoforms have been described. Isoform beta binds to focal adhesion kinase but weakly to vinculin. Isoform gamma binds to vinculin but only weakly to focal adhesion kinase. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 12q24.23
Cellular Component:  adherens junction; cell cortex; cytosol; focal adhesion; lamellipodium; microtubule associated complex; plasma membrane; stress fiber
Molecular Function:  beta-catenin binding; integrin binding; metal ion binding; neuropilin binding; protein binding; protein kinase binding; protein phosphatase binding; ubiquitin protein ligase binding; vinculin binding
Biological Process:  cell adhesion; cell-matrix adhesion; cellular response to reactive oxygen species; endothelial cell migration; growth hormone receptor signaling pathway; muscle contraction; positive regulation of stress fiber assembly; signal complex assembly; signal transduction; transforming growth factor beta receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway
Reference #:  P49023-2 (UniProtKB)
Alt. Names/Synonyms: FLJ16691; PAXI; Paxillin; PXN
Gene Symbols: PXN
Molecular weight: 60,967 Da
Basal Isoelectric point: 5.92  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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PXN iso2

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein