KIF24 Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation. Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Microtubule-binding; Motor
Chromosomal Location of Human Ortholog: 9p13.3
Cellular Component:  centriole; cytosol; protein-containing complex
Molecular Function:  ATP binding; identical protein binding; microtubule motor activity; protein binding
Biological Process:  ciliary basal body-plasma membrane docking; cilium assembly; microtubule depolymerization
Reference #:  Q5T7B8 (UniProtKB)
Alt. Names/Synonyms: bA571F15.4; C9orf48; FLJ10933; FLJ43884; KIF24; kinesin family member 24; Kinesin-like protein KIF24; MGC125677; MGC125678
Gene Symbols: KIF24
Molecular weight: 151,903 Da
Basal Isoelectric point: 6.69  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene