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P130Cas
Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells. Belongs to the CAS family. Widely expressed with an abundant expression in the testis. Low level of expression seen in the liver, thymus, and peripheral blood leukocytes. The protein has been detected in a B-cell line. 8 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis |
| Chromosomal Location of Human Ortholog: 8|8 E1 |
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Cellular Component:
actin cytoskeleton; cell junction; cytoplasm; focal adhesion; lamellipodium; plasma membrane; ruffle
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Molecular Function:
protein binding; protein domain specific binding; protein kinase binding; SH3 domain binding
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Biological Process:
actin cytoskeleton organization; actin filament organization; actin filament reorganization; antigen receptor-mediated signaling pathway; B cell receptor signaling pathway; cell adhesion; cell chemotaxis; cell migration; cellular response to endothelin; cellular response to hepatocyte growth factor stimulus; cellular response to nitric oxide; epidermal growth factor receptor signaling pathway; G protein-coupled receptor signaling pathway; hepatocyte growth factor receptor signaling pathway; insulin receptor signaling pathway; integrin-mediated signaling pathway; negative regulation of substrate adhesion-dependent cell spreading; neurotrophin TRK receptor signaling pathway; platelet-derived growth factor receptor signaling pathway; positive regulation of cell migration; positive regulation of endothelial cell migration; signal transduction; vascular endothelial growth factor receptor signaling pathway
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Reference #:
Q61140
(UniProtKB)
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Alt. Names/Synonyms: AI385681; Bcar1; breast cancer anti-estrogen resistance 1; Breast cancer anti-estrogen resistance protein 1; Cas; CRK-associated substrate; Crkas; p130; p130 Cas; p130cas; v-crk-associated tyrosine kinase substrate
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Gene Symbols: Bcar1
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Molecular weight:
94,285 Da
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Basal Isoelectric point:
5.4
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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ErbB/HER Signaling
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Growth And Differentiation Control by MAPKs
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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