Rb-like 2 Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor. Belongs to the retinoblastoma protein (RB) family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor; Tumor suppressor
Chromosomal Location of mouse Ortholog: 8 C4|8 44.25 cM
Cellular Component:  chromatin; cytosol; nucleolus; nucleus; transcription factor complex
Molecular Function:  DNA binding; promoter-specific chromatin binding; protein binding; RNA polymerase II activating transcription factor binding; RNA polymerase II regulatory region DNA binding
Biological Process:  cell cycle; cell differentiation; chromatin organization; negative regulation of G1/S transition of mitotic cell cycle; negative regulation of gene expression; regulation of cell cycle; regulation of cell division; regulation of lipid kinase activity; regulation of mitotic cell cycle; regulation of transcription by RNA polymerase II
Reference #:  Q64700 (UniProtKB)
Alt. Names/Synonyms: 130 kDa retinoblastoma-associated protein; p13; p130; pRb2; RB transcriptional corepressor like 2; Rb-like 2; Rb2; Rbl2; RBR-2; retinoblastoma-like 2; Retinoblastoma-like protein 2; Retinoblastoma-related protein 2
Gene Symbols: Rbl2
Molecular weight: 127,485 Da
Basal Isoelectric point: 7.7  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Rb-like 2

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene