Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. Specifically regulates nitric-oxide-generated cGMP. Belongs to the cyclic nucleotide phosphodiesterase family. Expressed in aortic smooth muscle cells, heart, placenta, skeletal muscle and pancreas and, to a much lesser extent, in brain, liver and lung. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 184.108.40.206; Nucleotide Metabolism - purine; Phosphodiesterase
Molecular Function: 3',5'-cyclic-GMP phosphodiesterase activity; 3',5'-cyclic-nucleotide phosphodiesterase activity; cGMP binding; cyclic-nucleotide phosphodiesterase activity; metal ion binding
Biological Process: cGMP catabolic process; cGMP metabolic process; negative regulation of cardiac muscle contraction; negative regulation of T cell proliferation; nervous system development; positive regulation of apoptotic process; positive regulation of cardiac muscle hypertrophy; positive regulation of chronic inflammatory response; positive regulation of MAP kinase activity; positive regulation of oocyte development; positive regulation of vasoconstriction; regulation of nitric oxide mediated signal transduction; regulation of the force of heart contraction; relaxation of cardiac muscle; response to hypoxia; response to lipopolysaccharide; response to testosterone; short-term memory; signal transduction; vasodilation