PDE5A Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. Specifically regulates nitric-oxide-generated cGMP. Belongs to the cyclic nucleotide phosphodiesterase family. Expressed in aortic smooth muscle cells, heart, placenta, skeletal muscle and pancreas and, to a much lesser extent, in brain, liver and lung. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Nucleotide Metabolism - purine; Phosphodiesterase
Chromosomal Location of Human Ortholog: 2q42
Cellular Component:  cytosol
Molecular Function:  3',5'-cyclic-GMP phosphodiesterase activity; 3',5'-cyclic-nucleotide phosphodiesterase activity; cGMP binding; cyclic-nucleotide phosphodiesterase activity; metal ion binding
Biological Process:  cGMP catabolic process; cGMP metabolic process; negative regulation of cardiac muscle contraction; negative regulation of T cell proliferation; nervous system development; positive regulation of apoptotic process; positive regulation of cardiac muscle hypertrophy; positive regulation of chronic inflammatory response; positive regulation of MAP kinase activity; positive regulation of oocyte development; positive regulation of vasoconstriction; regulation of nitric oxide mediated signal transduction; regulation of the force of heart contraction; relaxation of cardiac muscle; response to hypoxia; response to lipopolysaccharide; response to testosterone; short-term memory; signal transduction; vasodilation
Reference #:  O54735 (UniProtKB)
Alt. Names/Synonyms: CGB-PDE; cGMP-binding cGMP specific phosphodiesterase 5A2; cGMP-binding cGMP-specific phosphodiesterase; cGMP-specific 3',5'-cyclic phosphodiesterase; Pde5; Pde5a; PDE5A2; phosphodiesterase 5A, cGMP-specific
Gene Symbols: Pde5a
Molecular weight: 94,556 Da
Basal Isoelectric point: 5.74  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene