PDGFRA Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor. Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. Detected in platelets (at protein level). Widely expressed. Detected in brain, fibroblasts, smooth muscle, heart, and embryo. Expressed in primary and metastatic colon tumors and in normal colon tissue. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Oncoprotein; PDGFR family; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of Human Ortholog: 5 C3.3|5 39.55 cM
Cellular Component:  axon; cell junction; cell projection; cell surface; cilium; cytoplasm; external side of plasma membrane; Golgi apparatus; integral component of membrane; integral component of plasma membrane; intrinsic component of plasma membrane; membrane; microvillus; nucleus; plasma membrane; protein-containing complex; receptor complex
Molecular Function:  ATP binding; kinase activity; nucleotide binding; phosphatidylinositol 3-kinase binding; platelet-derived growth factor alpha-receptor activity; platelet-derived growth factor binding; platelet-derived growth factor receptor binding; protein homodimerization activity; protein kinase activity; protein tyrosine kinase activity; protein-containing complex binding; transferase activity; transmembrane receptor protein tyrosine kinase activity; vascular endothelial growth factor binding; vascular endothelial growth factor-activated receptor activity
Biological Process:  adrenal gland development; anatomical structure morphogenesis; animal organ morphogenesis; cardiac myofibril assembly; cell chemotaxis; cell migration; cellular response to amino acid stimulus; cellular response to reactive oxygen species; chemotaxis; embryonic cranial skeleton morphogenesis; embryonic digestive tract morphogenesis; estrogen metabolic process; extracellular matrix organization; face morphogenesis; female gonad development; hematopoietic progenitor cell differentiation; in utero embryonic development; Leydig cell differentiation; lung development; lung growth; luteinization; male genitalia development; metanephric glomerular capillary formation; multicellular organism development; negative regulation of platelet activation; odontogenesis of dentin-containing tooth; peptidyl-tyrosine phosphorylation; phosphatidylinositol-mediated signaling; phosphorylation; platelet aggregation; platelet-derived growth factor receptor signaling pathway; platelet-derived growth factor receptor-alpha signaling pathway; positive regulation of branching involved in lung morphogenesis; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway; positive regulation of cytosolic calcium ion concentration; positive regulation of ERK1 and ERK2 cascade; positive regulation of fibroblast proliferation; positive regulation of MAPK cascade; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of phospholipase C activity; protein autophosphorylation; protein phosphorylation; regulation of chemotaxis; regulation of mesenchymal stem cell differentiation; retina vasculature development in camera-type eye; roof of mouth development; signal transduction involved in regulation of gene expression; skeletal system morphogenesis; transmembrane receptor protein tyrosine kinase signaling pathway; wound healing
Reference #:  P26618 (UniProtKB)
Alt. Names/Synonyms: AI115593; Alpha platelet-derived growth factor receptor; Alpha platelet-derived growth factor receptor precursor (PDGF-R-alpha); Alpha-type platelet-derived growth factor receptor; CD140; CD140 antigen-like family member A; CD140a; PDGF alpha chain; PDGF-R-alpha; Pdgfr; PDGFR alpha; Pdgfr-2; PDGFR-alpha; Pdgfra; PGFRA; platelet derived growth factor receptor, alpha polypeptide; Platelet-derived growth factor alpha receptor; Platelet-derived growth factor receptor alpha
Gene Symbols: Pdgfra
Molecular weight: 122,683 Da
Basal Isoelectric point: 5.03  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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PDGFRA

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene