treacle Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification. Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification. 8 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Nucleolus; RNA-binding; Transcription, coactivator/corepressor
Cellular Component: 
Reference #:  E1BHU1 (UniProtKB)
Alt. Names/Synonyms: TCOF1; treacle; treacle ribosome biogenesis factor 1
Gene Symbols: TCOF1
Molecular weight: 151,295 Da
Basal Isoelectric point: 9.23  Predict pI for various phosphorylation states
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treacle

Protein Structure Not Found.

Cross-references to other databases:  Pfam  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene