FOXO3A Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy. Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins. Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation. In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Autophagy; DNA-binding; Oncoprotein; Transcription factor
Chromosomal Location of mouse Ortholog: 10 B2|10 22.79 cM
Cellular Component:  cytoplasm; cytosol; membrane; mitochondrial outer membrane; mitochondrion; nucleoplasm; nucleus; protein-containing complex
Molecular Function:  beta-catenin binding; chromatin DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; mitochondrial sequence-specific DNA-binding transcription factor activity; protein binding; protein kinase binding; RNA polymerase II proximal promoter sequence-specific DNA binding; sequence-specific DNA binding; transcription cofactor binding; transcription factor binding
Biological Process:  aging; antral ovarian follicle growth; apoptotic process; brain morphogenesis; cellular response to oxidative stress; DNA damage response, signal transduction by p53 class mediator; extrinsic apoptotic signaling pathway in absence of ligand; glucose homeostasis; initiation of primordial ovarian follicle growth; insulin receptor signaling pathway; mitochondrial transcription; negative regulation of canonical Wnt signaling pathway; negative regulation of cell migration; negative regulation of neuron differentiation; negative regulation of transcription by RNA polymerase II; neuronal stem cell population maintenance; oocyte maturation; ovulation from ovarian follicle; positive regulation of apoptotic process; positive regulation of autophagy; positive regulation of endothelial cell apoptotic process; positive regulation of erythrocyte differentiation; positive regulation of hydrogen peroxide-mediated programmed cell death; positive regulation of muscle atrophy; positive regulation of neuron apoptotic process; positive regulation of reactive oxygen species biosynthetic process; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; regulation of neural precursor cell proliferation; regulation of reactive oxygen species metabolic process; regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; regulation of translation; response to starvation; tumor necrosis factor-mediated signaling pathway
Reference #:  Q9WVH4 (UniProtKB)
Alt. Names/Synonyms: 1110048B16Rik; 2010203A17Rik; C76856; FKHR; Fkhr2; FKHRL1; forkhead box O3; Forkhead box O3a; Forkhead box protein O3; Forkhead protein FKHR2; Fox; Foxo3; Foxo3a; OTTMUSP00000022929; OTTMUSP00000022930
Gene Symbols: Foxo3
Molecular weight: 71,064 Da
Basal Isoelectric point: 4.92  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  G1/S Checkpoint  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Insulin Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene