CENPA Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis. Belongs to the histone H3 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 5 B1|5 16.76 cM
Cellular Component:  chromosome; chromosome, centromeric region; condensed chromosome inner kinetochore; condensed nuclear chromosome kinetochore; condensed nuclear chromosome, centromeric region; kinetochore; nuclear nucleosome; nuclear pericentric heterochromatin; nucleoplasm; nucleosome; nucleus
Molecular Function:  DNA binding; nucleosomal DNA binding; protein heterodimerization activity
Biological Process:  establishment of mitotic spindle orientation; kinetochore assembly; mitotic cytokinesis; protein localization to chromosome, centromeric region
Reference #:  O35216 (UniProtKB)
Alt. Names/Synonyms: Cen; CENP-A; Cenpa; centromere autoantigen A; Centromere protein A; centrosomin A; Histone H3-like centromeric protein A; OTTMUSP00000025185
Gene Symbols: Cenpa
Molecular weight: 15,509 Da
Basal Isoelectric point: 11.27  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene