|
PDHA1
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. Ubiquitous. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 1.2.4.1; Mitochondrial; Oxidoreductase |
| Chromosomal Location of mouse Ortholog: X F4|X 73.95 cM |
|
Cellular Component:
catalytic complex; intracellular membrane-bounded organelle; mitochondrial pyruvate dehydrogenase complex; mitochondrion; nucleolus; pyruvate dehydrogenase complex
|
|
Molecular Function:
oxidoreductase activity; oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; protein binding; pyruvate dehydrogenase (acetyl-transferring) activity; pyruvate dehydrogenase (NAD+) activity; pyruvate dehydrogenase activity
|
|
Biological Process:
acetyl-CoA biosynthetic process from pyruvate; carbohydrate metabolic process; glucose metabolic process; tricarboxylic acid cycle
|
|
Reference #:
P35486
(UniProtKB)
|
|
Alt. Names/Synonyms: ODPA; OTTMUSP00000020974; Pdha; Pdha-1; Pdha1; PDHE1-A type I; pyruvate dehydrogenase E1 alpha 1; Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; pyruvate dehydrogenase E1alpha subunit
|
|
Gene Symbols: Pdha1
|
|
Molecular weight:
43,232 Da
|
|
Basal Isoelectric point:
8.49
Predict pI for various phosphorylation states
|
|
CST Pathways:
Warburg Effect
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
