PFKFB2 Synthesis and degradation of fructose 2,6-bisphosphate. In the C-terminal section; belongs to the phosphoglycerate mutase family. Heart. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - fructose and mannose; EC; EC; Kinase, other; Motility/polarity/chemotaxis; Phosphatase (non-protein)
Chromosomal Location of mouse Ortholog: 1|1 E4
Cellular Component:  cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function:  6-phosphofructo-2-kinase activity; fructose-2,6-bisphosphate 2-phosphatase activity; kinase binding; protein kinase binding
Biological Process:  fructose 2,6-bisphosphate metabolic process; glucose catabolic process; glycolytic process; lactate metabolic process; positive regulation of glucokinase activity; positive regulation of insulin secretion; pyruvate metabolic process; response to glucose
Reference #:  P70265 (UniProtKB)
Alt. Names/Synonyms: 4930568D07Rik; 6-phosphofructo-2-kinase; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2; 6PF-2-K/Fru-2,6-P2ase 2; 6PF-2-K/Fru-2,6-P2ase heart-type isozyme; F262; Fructose-2,6-bisphosphatase; PFK-2/FBPase-2 gene B; PFK/FBPase 2; Pfkfb2
Gene Symbols: Pfkfb2
Molecular weight: 59,925 Da
Basal Isoelectric point: 8.34  Predict pI for various phosphorylation states
CST Pathways:  PI3K/Akt Signaling  |  Warburg Effect
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene