MSK2 Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: AGC group; EC 2.7.11.1; Kinase, protein; MSK subfamily; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); RSK family
Chromosomal Location of human Ortholog: 11q13.1
Cellular Component:  cytoplasm; cytosol; nucleoplasm; nucleus; synapse
Molecular Function:  ATP binding; histone H3S10 kinase activity; histone H3S28 kinase activity; magnesium ion binding; protein binding; protein serine kinase activity; protein serine/threonine kinase activity; ribosomal protein S6 kinase activity
Biological Process:  chromatin remodeling; inflammatory response; interleukin-1-mediated signaling pathway; intracellular signal transduction; negative regulation of cytokine production; peptidyl-serine phosphorylation; positive regulation of CREB transcription factor activity; positive regulation of NF-kappaB transcription factor activity; positive regulation of transcription by RNA polymerase II; post-translational protein modification; protein phosphorylation; regulation of DNA-templated transcription
Reference #:  O75676 (UniProtKB)
Alt. Names/Synonyms: 90 kDa ribosomal protein S6 kinase 4; KS6A4; mitogen- and stress-activated protein kinase 2; MSK2; Nuclear mitogen- and stress-activated protein kinase 2; Ribosomal protein kinase B; ribosomal protein S6 kinase A4; ribosomal protein S6 kinase alpha 4; Ribosomal protein S6 kinase alpha-4; ribosomal protein S6 kinase, 90kDa, polypeptide 4; RPS6KA4; RSK-B; RSKB; S6K-alpha-4
Gene Symbols: RPS6KA4
Molecular weight: 85,606 Da
Basal Isoelectric point: 8.51  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Regulation of P38 MAPKs
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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MSK2

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein